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US 8,575,185 B2Granted
Compositions, synthesis, and methods of utilizing quinazolinedione derivatives
AssigneeReviva Pharmaceuticals, Inc.
InventorsLaxminarayan Bhat, Prabhu Prasad Mohapatra, Sureshbabu Dadiboyena, Kouacou Adiey
Life of this patent
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Abstract
The present invention provides quinazolinedione derivatives of Formulae Ia and Ib, which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic disorder, depression and dementia.
Claims25
A compound according to Formula (1):
- wherein:
- A is —O—(CH2)n—, —S—(CH2)n—, —CH2—O—(CH2)n—, —(CH2)n—O—CH2—CH2—, —CH2—S—(CH2)n—, or —(CH2)n—S—CH2—CH2—, wherein n is an integer from 1 to 7;
- H is
- R1, R2, R3, R4, R5, and R6 is each independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, alkoxy, alkylthio, amino, alkylamino, arylalkylamino, dialkylamino, arylalkoxy, carboxy, carbamoyl, carbamate, carbonate, cyano, halo, or hydroxy, wherein each hydrogen of R1, R2, R3, R4, R5, R6 and A is optionally substituted with 2H (deuterium);
- or a pharmaceutically acceptable salt, racemate or diastereomeric mixture thereof.
2 more elements
A compound according to Formula (1b):
- wherein:
- A is —(CH2)n—, —O—(CH2)n—, —S—(CH2)n—, —S(O)(O)—(CH2)n—, —NH—(CH2)n—, —CH2—O—(CH2)n—, —(CH2)n—O—CH2—CH2—, —CH2—S—(CH2)n—, —(CH2)n—S—CH2—CH2—, —CH2—S(O)(O)—(CH2)n—, —(CH2)n—S(O)(O)—CH2—CH2—, —O—C(O)—(CH2)n—, —S—C(O)—(CH2)n—, —NH—C(O)—(CH2)n—, —CH2—C(O)—O—(CH2)n—, —CH2—C(O)—NH—(CH2)n—, —CH2—C(O)—S—(CH2)n—, —(CH2)n—C(O)—O—CH2—CH2—, —(CH2)n—C(O)—NH—CH2—CH2—, —(CH2)n—C(O)—S—CH2—CH2—, —CH2—O—C(O)—(CH2)n—, —CH2—NH—C(O)—(CH2)n—, —CH2—S—C(O)—(CH2)n—, —(CH2)n—O—C(O)—CH2—CH2—, (CH2)n—NH—C(O)—CH2—CH2—, or (CH2)n—S—C(O)—CH2—CH2—, wherein n is an integer from 1 to 7;
- R1, R2, R3, R4, R5, and R6 is each independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, alkoxy, alkylthio, amino, alkylamino, arylalkylamino, dialkylamino, arylalkoxy, carboxy, carbamoyl, carbamate, carbonate, cyano, halo, or hydroxy, wherein each hydrogen of R1, R2, R3, R4, R5, R6 and A is optionally substituted with 2H (deuterium);
- or a pharmaceutically acceptable salt, racemate or diastereomeric mixture thereof.
1 more element
Dependencies are inferred from the claim text.