Dihydropyrazolopyrimidinone derivatives

A compound represented by the general formula (I), or a pharmaceutically acceptable salt thereof:

• wherein,
• Ar1 is a phenyl group, which is optionally substituted with a substituent selected from the group consisting of a halogen atom, a C1-C6 alkyl group, a halo-C1-C6 alkyl group, a hydroxy-C1-C6 alkyl group, a C1-C6 alkoxy group, a C2-C7 alkanoyl group, a hydroxy-C1-C6 alkylamino group, a carbamoyl group, a hydroxy-C1-C6 alkylcarbamoyl group, a heteroaryl group optionally substituted with a C1-C6 alkyl group, and a group represented by -Q1-A1-Q2-A2(R1a)R1b;
• A1 is a single bond, an oxygen atom or a sulfur atom, or is an imino group optionally substituted with a C1-C6 alkyl group;
• A2 is a nitrogen atom, or is a methine group optionally substituted with a hydroxy group, a C1-C6 alkyl group or a hydroxy-C1-C6 alkyl group;
• Q1 is a single bond, a carbonyl group or a methylene group optionally substituted with a C1-C6 alkyl group;
• Q2 is a single bond or an ethylene or trimethylene group optionally substituted with a C1-C6 alkyl group;
• R1a and R1b are each independently a hydrogen atom, a C1-C6 alkyl group or a hydroxy-C1-C6 alkyl group, or together form a C1-C6 alkylene group, wherein one or two or more methylene groups constituting the C1-C6 alkylene group may be independently replaced with an oxygen atom, a sulfur atom, a sulfinyl group, a sulfonyl group, a carbonyl group, a vinylene group or a group represented by —N(R1c)—, or substituted with a hydroxy group, a C1-C6 alkyl group or a group represented by —R10c;
• R1c is a hydrogen atom, a formyl group, a C2-C6 alkenyl group or a group represented by -Q3-A3(R1d)R1e;
• R10c is a group represented by -Q30-A30(R10d)R10e;
• A3 and A30 are each independently a nitrogen atom, or a methine group optionally substituted with a hydroxy group, a C1-C6 alkyl group or a hydroxy-C1-C6 alkyl group;
• Q3 and Q30 are each independently a single bond or a C1-C6 alkylene group, wherein one or two or more methylene groups constituting the C1-C6 alkylene group may be independently replaced with an oxygen atom, a sulfur atom, a carbonyl group, a sulfinyl group or a sulfonyl group, or substituted with a halogen atom, a cyano group, a hydroxy group or a C1-C6 alkyl group;
• R1d and R1e are each independently a hydrogen atom, a halogen atom, a cyano group, a hydroxy group, a C1-C6 alkyl group or a hydroxy-C1-C6 alkyl group, or together form a C1-C6 alkylene group, wherein one or two or more methylene groups constituting the C1-C6 alkylene group may be independently replaced with an oxygen atom, a sulfur atom, a sulfinyl group, a sulfonyl group, a carbonyl group, a vinylene group or a group represented by —N(R1f)—, or substituted with a hydroxy group or a C1-C6 alkyl group;
• R1f and R10f are each independently a hydrogen atom, a C1-C6 alkyl group, a halo-C1-C6 alkyl group, a C2-C6 alkenyl group or a C2-C7 alkanoyl group;
• R10d and R10e are each independently a hydrogen atom, a halogen atom, a cyano group, a hydroxy group, a C1-C6 alkyl group or a hydroxy-C1-C6 alkyl group, or together form a C1-C6 alkylene group, wherein one or two or more methylene groups constituting the C1-C6 alkylene group may be independently replaced with an oxygen atom, a sulfur atom, a sulfinyl group, a sulfonyl group, a carbonyl group, a vinylene group or a group represented by —N(R10f)—, or substituted with a hydroxy group or a C1-C6 alkyl group;
• R1 is a hydrogen atom, or is a C1-C6 alkyl group which is optionally substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, a cyano group, a C1-C6 alkoxy group, a C3-C6 cycloalkyl group, a C2-C7 alkanoyl group and a C1-C6 alkylsulfonyl group, or is an aryl, aralkyl or heteroaryl group which is optionally substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, a cyano group, an amino group, a C1-C6 alkyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkyl group and a hydroxy-C1-C6 alkyl group;
• R2 is a C1-C6 alkyl group substituted with one or two phenyl groups, or is a group represented by the formula (a):
• R2a is a hydrogen atom, a halogen atom, a hydroxy group, a cyano group, an amino group, a nitro group, a carbamoyl group, a C1-C6 alkyl group, a C1-C6 alkylsulfonyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkyl group, a hydroxy-C1-C6 alkyl group or a C1-C6 alkoxy-C1-C6 alkyl group;
• T, U, V and W are each independently a methine group, which is optionally substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, a cyano group, an amino group, a nitro group, a carbamoyl group, a C1-C6 alkyl group, a C1-C6 alkylsulfonyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkyl group, a hydroxy-C1-C6 alkyl group and a C1-C6 alkoxy-C1-C6 alkyl group, or one of T, U, V, and W is a nitrogen atom;
• and
• R3 is a hydrogen atom or a C1-C6 alkyl group.