US 8,575,178 B2 · Isothiazolo-pyrimidinedione derivatives as TRPA1 modulators

Abstract

The present invention is related to novel isothiazolo[3,4-d]pyrimidinedione and isothiazolo[5,4-d]pyrimidinedione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

Claims15

Dependent claims

The compound having the structure (Id)

or a pharmaceutically acceptable salt thereof;
wherein,
R1 and R2, which may be the same or different, are each independently hydrogen or (C1-C4)alkyl;
R4, R5, R6, R7, R8 and R9, which may be same or different, are each independently selected from the group comprising of hydrogen, halogen, cyano, hydroxyl, nitro, amino, substituted or unsubstituted alkyl, alkoxy, haloalkyl, haloalkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkylalkoxy, aryl, arylalkyl, biaryl, heteroaryl, heteroarylalkyl, heterocyclic ring and heterocyclylalkyl.

1 more element

Dependencies are inferred from the claim text.

Isothiazolo-pyrimidinedione derivatives as TRPA1 modulators

Life of this patent

Isothiazolo-pyrimidinedione derivatives as TRPA1 modulators

Life of this patent

Abstract

Claims15