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US 8,575,176 B2Granted
Heteroaromatic pyrazinoylguanidine sodium channel blockers
AssigneeParion Sciences, Inc.
InventorMichael Ross Johnson
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Abstract
Polyaromatic sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.
Claims6
A compound represented by the formula III:
- and pharmaceutically acceptable salts thereof, wherein:
- A2 is represented by the formula:
- wherein one Q is a nitrogen atom, five Q are carbon atoms and one Q is C—R5;
- R5 is —O—CH2—(CHOH)—CH2OH, —OH, —O—(CH2)3NH2, —O—(CH2)3NH(C═NH)NH2, —O—(CH2)2NH(C═NH)NH2, —O—CH2(CO)NH2, —O—(CH2)2—N⊕—(CH3)3,
1 more element
Dependencies are inferred from the claim text.