Therapeutic agent for chronic renal failure
AssigneeToray Industries, Inc.
InventorsFuko Matsuda, Katsuhiko Iseki, Hajimu Kurumatani, Mitsuko Miyamoto
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Abstract
The present invention aims to provide a therapeutic agent for chronic renal failure, comprising as an effective ingredient a compound represented by General Formula (1) or a pharmaceutically acceptable salt thereof. That is, the present invention provides provision of a drug comprising as an effective ingredient a compound represented by General Formula (1) or a pharmaceutically acceptable salt thereof, which drug is useful not only for amelioration of renal function, but also for amelioration of anemia, activation of SOD and excretion of uremic substances.
Claims6
A method for the treatment of chronic renal failure, which comprises administering to a patient in need thereof an effective amount of a compound represented by General Formula (1) below:
- wherein
- R1 and R2 each independently represents aryl;
- A represents NR5, O, S, SO or SO2;
- R5 represents C1-C6 alkyl, C2-C6 alkenyl or C3-C6 cycloalkyl;
- D represents C2-C6 alkylene or alkenylene;
- G represents O, S, SO or SO2;
- R3 and R4 each independently represents hydrogen or C1-C6 alkyl;
- and
- Q represents carboxyl, C1-C6 alkoxycarbonyl, tetrazolyl or General Formula (2) below:
- —CONH—SO2—R6 (2)
- wherein R6 represents C1-C6 alkyl;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.