Piperazinyl 3-aminopyrrolidine derivatives as a CCR2 antagonists

Compound having the following formula I

• wherein:
• R1 can be independently selected from the group consisting of hydrogen atom, C1-C3 alkyl, phenyl, benzyl, benzoyl, benzensulfonyl, C1-C3 alkylcarbonyl, C3-C7 cycloalkyl, the formula II, III and IV;
• R10, R11 and R12 can be independently selected from the group consisting of hydrogen atom, C1-C3 alkyl, phenyl, and benzyl;
• all benzene groups included as part of R1 can have a plurality of substituents independently selected from the group consisting of C1-C3 alkyl, C1-C2 haloalkyl, halogen atom and cyano;
• R2, R3, R4, R5, R6, R7, R8 and R9 can be independently selected from hydrogen atom and C1-C3 alkyl;
• R6 and R7, R8 and R9 can be independently selected as carbonyl group;
• wherein said halogen is selected from the group consisting of fluorine, chlorine and bromine atom.