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US 8,575,170 B2Granted
Flurbiprofen analogs and methods of use in treating cancer
AssigneeThe Regents of the Unversity of Colorado, a body corporate
InventorsLajos Gera, Daniel C. Chan, Robert S. Hodges, Paul A. Bunn
Life of this patent
Estimating the term…
Abstract
Flurbiprofen analog compounds having an amino acid derivatized at the flurbiprofen alkanoic acid carboxyl group and terminating at an ester or amide group are effective in inhibiting cancer cells in vitro and inhibiting the growth of cancers in viva. The compounds and pharmaceutical compositions containing them are particularly useful for the treatment of lung, pancreatic and head and neck cancers.
Claims17
A compound having the structural formula:
- including pharmaceutically acceptable salts thereof, where
- R1 is selected from H or a 1-4 carbon alkyl,
- R2 is selected from F, Cl, and Br and may include two or more R2 substitutions on the ring,
- R3 is selected from H, F, Cl and Br, and may include two or more non-H substitutions on the ring,
- —NH—CH(R4)—C(O)— is a hydrophobic amino acid residue, and
- R5 is 1-(3-Aminopropyl)-4-methylpiperazine (Amp) or 4-Amino-2,2,6,6-tetramethylpiperidine (Atmp).
3 more elements
A compound having a structural formula selected from the group consisting of:
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.