Imidazole derivatives as aldosterone synthase inhibitors

A compound of Formula I:

• wherein:
• R1 and R2 are independently OH, C2-7alkenyloxy, C2-7alkoxy, C6-10aryl, aryl-C2-7alkenyl, C2-7alkenyl, C3-8cycloalkyl, C2-7alkynyl, C1-7cycloalkyl-C2-7alkynyl, heteroaryl, heteroaryl-C1-7alkyl, —CH2C(O)OH, —CH2C(O)O—C1-7alkyl, —CH2C(O)NH—C6-10aryl, —CH2C(O)NH-heteroaryl, —CH2C(O)-heterocyclyl, —CH2C(O)NH-heterocyclyl, —CH2C(O)NH—C1-7alkyl, —C(O)O—C1-7alkyl or —C(O)—C1-7alkyl;
• wherein aryl, heterocyclyl and heteroaryl are optionally substituted with one or more R6;
• with the proviso that one of R1 and R2 is other than C1-7alkyl;
• or
• R1 and R2 form together ═O, ═N(OH) or ═N(O—C1-7alkyl);
• and
• R3 and R4 are independently selected from the group consisting of H, hydroxy, aryl-C1-7alkyl or halo;
• wherein aryl is optionally substituted with one or more R8;
• and
• R5 is H, halo, hydroxy or C2-7alkenyl;
• and
• R6 and R8 for each occurrence, is independently C1-7alkyl, C3-7cycloalkyl, CN, OH, NH2, C1-7alkylamino, di-(C1-7alkyl)amino, C6-10aryl, heteroaryl, C1-7alkoxy, halo, heterocyclyl, benzyloxy, halo-C1-7alkoxy, —OS(O)2—C1-7alkyl or —OS(O)2-halo C1-7alkyl;
• wherein C8-10aryl, heterocyclyl and heteroaryl are optionally substituted with one or more R9;
• for each occurrence, R7 is independently hydrogen, C2-7alkenyl, C3-8cycloalkyl, halo, nitro, cyano, NH2, haloC1-7alkyl, C1-7alkoxy, C3-8cycloalkoxy, C8-10aryloxy, C8-10aryl, heteroaryl, heteroaryl-C1-7alkyl, heterocyclyl, heterocyclyl-C1-7alkyl, C(O)OR10 or N(R11R12), wherein said alkyl, alkenyl, alkoxy, aryl, heterocyclyl and heteroaryl each are optionally substituted with one or more substituent independently selected from C1-7hydroxy, halo, halo C1-7alkyl, C1-7alkoxy, nitro, cyano, C1-7alkylamino and C1-7alkoxy-C1-7alkyl;
• R9 for each occurrence, is independently C1-7alkyl, C1-7alkoxy, halo, haloC1-7alkyl, NH2, C1-7alkylamino, di-(C1-7alkyl)amino, haloC1-7alkoxy, CN, OH, C(O)O—C1-7alkyl, C(O)O-haloC1-7alkyl, carbamoyl, C1-7-alkylaminocarbonyl or di-C1-7alkylaminocarbonyl;
• R10, R11 and R12 for each occurrence are independently H, C3-8cycloalkyl, halo-C1-7alkyl, C6-10aryl, C6-10aryl-C1-7alkyl, heteroaryl, heteroaryl-C1-7alkyl, heterocyclyl, heterocyclyl-C1-7alkyl;
• or R11 and R13 taken together with the nitrogen to which they are attached form a 3 to 8-membered heterocyclyl ring or a 5-membered heteroaryl ring;
• n is 0 or 1;
• p is 0, 1, 2, 3, 4 and 5;
• or a pharmaceutically acceptable salt thereof.