Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
AssigneesVitae Pharmaceuticals, Inc., Boehringer Ingelheim International GmbH
InventorsMartin Renz, Martin Schuehle, Zhenrong Xu
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Abstract
This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, lo1, lo2, lo5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
Claims19
A compound represented by the following structural formula:
- wherein the compound is a monohydrate and crystalline.
A compound represented by the following structural formula:
- wherein the compound is a monohydrate and crystalline.
A compound represented by the following structural formula:
- wherein the compound is a monohydrate and crystalline.
Dependencies are inferred from the claim text.