Pyridine-3-carboxyamide derivative

A pyridine-3-carboxyamide derivative represented by the general formula (1):

• wherein
• R1 is a group selected from one of the following formulas i to iv:
• wherein
• R6 is selected from the group consisting of a hydrogen atom, a C1-6 alkyl group and an optionally substituted acyl group,
• R7, R8, R9, R10 and R11, which may be the same or different, are selected from the group consisting of a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, a cyano group, an optionally substituted C3-8 cycloalkyl group, a C1-6 alkoxycarbonyl group, an optionally substituted C1-6 alkylcarbonyl group, a C3-8 cycloalkylcarbonyl group, a carbamoyl group, a carboxyl group, a C1-6 alkylthio group, a C1-6 alkylsulfinyl group, a C1-6 alkylsulfonyl group, a (5-11-membered heterocyclic)-sulfonyl group, an optionally substituted 5-11-membered heterocyclic group, an optionally substituted sulfamoyl group, —O—R21 (wherein R21 represents a hydrogen atom, an optionally substituted C1-6 alkyl group or a piperazinyl group that may be substituted with a C1-6 alkyl group), —NR22R23 (wherein R22 and R23, which may be the same or different, represent a hydrogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted C1-6 alkylsulfonyl group, a C2-6 alkenylsulfonyl group or an optionally substituted 5-11-membered heterocyclic group) and —NR24COR25 (wherein R24 represents a hydrogen atom or a C1-6 alkyl group, and R25 represents an amino group, a mono(C1-6 alkyl)amino group, a di(C1-6 alkyl)amino group or an optionally substituted 5-11-membered heterocyclic group),
• R12 represents a hydrogen atom or a sulfonyl group, and
• R13, R14, R15, R16, R17, R18, R19 and R20, which may be the same or different, represent a hydrogen atom, a halogen atom, a cyano group or a morpholino group,
• R2 represents a group selected from one of the following formulas v to x:
• R26 represents a hydrogen atom, a C1-6 alkyl group, a C6-10 aryl C1-6 alkyl group or a C1-6 alkylcarbonyl group,
• R27 represents a hydrogen atom or a C1-6 alkyl group,
• R28, R29, R30, R31 and R32, which may be the same or different, are selected from the group consisting of a hydrogen atom, a halogen atom, a C1-6 alkyl group, a halo C1-6 alkyl group, a C1-6 alkoxy group, a carboxyl group, a C1-6 alkoxycarbonyl group, a carbamoyl group, a nitro group, a piperazinyl group that may be substituted with a C1-6 alkyl group, an amino group, a mono(C1-6 alkyl)amino group, a di(C1-6 alkyl)amino group, a C1-6 alkylcarbonylamino group, —N(R34)SO2R35 (wherein R34 represents a hydrogen atom or a C1-6 alkyl group and R35 represents a C1-6 alkyl group or a C2-6 alkenyl group) and —SO2NR36R37 (wherein R36 and R37, which may be the same or different, represent a hydrogen atom or a C1-6 alkyl group), or R28 and R29 or R29 and R30 may together form a benzene ring,
• R33 represents a hydrogen atom or a C1-6 alkyl group,
• m represents an integer of 1 to 6,
• n represents 0 or 1,
• R3 represents a hydrogen atom or a C1-6 alkyl group and
• R4 and R5, which may be the same or different, are selected from the group consisting of a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, an amino group and a hydroxy group],
• or its salt or a hydrate thereof.