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US 8,575,147 B2Granted
Spontaneously dispersible N-benzoyl staurosporine compositions
AssigneeNovartis AG
InventorsGraham Paul Matthews, Barbara Haeberlin
Life of this patent
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Abstract
Spontaneously dispersible N-benzoyl-staurosporine compositions are discussed for oral administration having high bioavailability levels and reduced variability of bioavailability levels of N-benzoyl-staurosporine, as well as their preparation and use in medical treatment.
Claims12
A pharmaceutical unit dosage which is a capsule shell containing a pharmaceutical composition comprising
- (a) 5 to 10% by weight of N-benzoyl-staurosporine;
- (b) 15 to 35% by weight of a hydrophilic component which is a polyethylene glycol of a molecular weight of 100 to 600 daltons, or a mixture of ethanol and the polyethylene glycol of a molecular weight of 100 to 600 daltons;
- (c) 30 to 55% by weight of a surfactant which is a polyoxyethylene castor oil or a mixture of a polyoxyethylene castor oil with transesterified ethoxylated vegetable oil;
- (d) 20 to 50% by weight of a lipophilic component which is a medium chain fatty acid triglyceride or corn oil glyceride;
- and
- (e) 0.1 to 1% by weight of an additive which is an antioxidant or an antimicrobial agent;
- wherein said pharmaceutical composition is suitable for oral administration and is spontaneously dispersible when diluted in an aqueous medium.
4 more elements
A pharmaceutical composition which comprises
- (a) 5 to 10% by weight of N-benzoyl-staurosporine;
- (b) 15 to 35% by weight of a hydrophilic component which is a polyethylene glycol of a molecular weight of 100 to 600 daltons, or a mixture of ethanol and the polyethylene glycol of a molecular weight of 100 to 600 daltons;
- (c) 30 to 55% by weight of a surfactant which is a polyoxyethylene castor oil or a mixture of a polyoxyethylene castor oil with transesterified ethoxylated vegetable oil;
- (d) 20 to 50% by weight of a lipophilic component which is a medium chain fatty acid triglyceride or corn oil glyceride;
- and
- (e) 0.1 to 1% by weight of an additive which is an antioxidant or an antimicrobial agent;
- wherein said pharmaceutical composition is suitable for oral administration and is spontaneously dispersible when diluted in an aqueous medium.
4 more elements
Dependencies are inferred from the claim text.