Triazolopyridine compounds as PIM kinase inhibitors

A compound of general Formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• A is OR10 or NR11R12;
• B is H, F, Cl, ORa, (1-6C alkyl)NRbRc, (1-6C alkyl)OH, CH(OH)CH2OH, or (1-4C alkyl);
• R1 is H, F, Cl, Br, Me, cyclopropyl or CN;
• R1a, R2, R3 and R4 are independently H, F, Cl, Br, Me or CN;
• R5 and R7 are independently H, F, Me or CN;
• R6 is H, F, Me, Br, CN, cyclopropyl, phenyl, MeO— or MeOCH2CH2O—;
• R10 is H, hetCyc1, -(1-3C alkyl)hetCyc1a, hetCyc2, (CR17R18)p(CR13R14)CH2NR15R16, —(CR17R18)p(CR13R14)CH2OH, (1-6C alkyl), hetAr1, (1-3C alkyl)hetAr1a, or (3-7C)cycloalkyl substituted with NH2, NH(1-6C alkyl) or N(1-6C alkyl)2;
• R11 is H or (1-6C)alkyl;
• R12 is hetCyc3, (1-6C alkyl)NR15R16, C(O)(1-6C alkyl)NR15R16, (1-6C alkyl)NHC(O)O(1-6C alkyl), or (4-7C)cycloalkyl optionally substituted with OH, NH2, NH(1-6C alkyl) or N(1-6C alkyl)2;
• R13 is H, (1-6C)alkyl, F or OH, and
• R14 is H, (1-6C)alkyl or F, or
• R13 and R14 together with the carbon atom to which they are attached form a 3-6 membered carbocyclic ring;
• each R15, R16, R17 and R18 is independently H or (1-6C) alkyl,
• or each R15, R17 and R18 is independently H or (1-6C)alkyl and R16 is H, (1-6C)alkyl, C(═O)CH2F, CH2CHF2 or CH2CF3;
• or NR15R16 forms a 5-6 membered heterocyclic ring having a first ring heteroatom which is N and optionally having a second ring heteroatom selected from N and O;
• hetCyc1, hetCyc1a, and hetCyc3 are independently a 4-7 membered heterocycle having a ring nitrogen atom and optionally substituted with one or more R9 groups, or
• hetCyc1 and hetCyc3 are independently a 4-7 membered heterocycle having a ring nitrogen atom and optionally substituted with one or more R9 groups, and hetCyc1a is selected from a morpholinyl and 4-7 membered azacyclic ring optionally substituted with one or more R9 groups;
• each R9 is independently selected from halogen, (1-6C)alkyl, cyclopropylmethyl, benzyl, NRfRg, -(1-6C alkyl)NRhRi, ORj, (1-6C alkyl)ORk, (1-6C)fluoroalkyl, C(O)NRmRn, (1-6C alkyl)C(O)NRpRq, and C(O)O(1-6C alkyl);
• hetCyc2 is an 8-membered bridged heterocycle having a ring nitrogen atom;
• hetAr1 and hetAr1a are independently a 5 or 6 membered heteroaryl having 1-2 ring nitrogen atoms and optionally substituted with one or more substituents independently selected from F, Cl, Br, Me, cyclopropyl, CN, NH2, NH(1-6C alkyl) and N(1-6C alkyl)2;
• Ra is H, (1-6C alkyl), -(1-6C alkyl)-O-(1-6C alkyl) or -(1-6C alkyl)-O-(3-6C cycloalkyl);
• each Rb, Rc, Rf, Rg, Rh, Ri, Rk, Rm, Rp and Rq is independently selected from H and (1-6C alkyl);
• Rj is H, (1-6C alkyl) or cyclopropyl;
• Rn is H, (1-6C alkyl), —O(1-6C alkyl) or —O(3-6C cycloalkyl);
• and
• p is 0, 1 or 2.