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US 8,575,141 B2Granted
Steroid-derived cyclopamine analogs and methods for using the same in the prevention or treatment of cancer
AssigneesThe Wistar Institute, The Trustees of the University of Pennsylvania
InventorsNadia Dahmane, Jeffrey D. Winkler
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Abstract
The present invention relates to steroid-derived cyclopamine analogs and methods for using the same for inhibiting sonic hedgehog signaling and preventing or treating cancer. A method for synthesizing the analogs of the present invention from a steroid is also provided.
Claims6
A steroid-derived C-17 spirotetrahydrofuranyl cyclopamine analog with a 6/6/6/5 framework structure, wherein said analog inhibits sonic hedgehog signaling and has the structure:
Dependencies are inferred from the claim text.