Conjugate constructs, delivery, and use for treatment of disease

A method of treatment of infection by Toxoplasma gondii comprising contacting a patient with an effective amount of a pharmaceutical composition comprising a PPMO, wherein said PPMO is constructed by conjugation of a transductive peptide to a PMO oligonucleotide analog, wherein said PMO is an antisense phosphorodiamidate morpholino oligomer chosen from the set consisting of SEQ ID NO 3, SEQ ID NO 4, SEQ ID NO 5, SEQ ID NO 7 and SEQ ID NO 8, and wherein said transductive peptide is chosen from the set consisting of SEQ ID NO 9, SEQ ID NO 10, SEQ ID NO 11, SEQ ID NO 12, SEQ ID NO 13, SEQ ID NO 14, SEQ ID NO 15, SEQ ID NO 16, SEQ ID NO 17, and SEQ ID NO 18.