Compositions and methods for treating cancer

A method for treating a cancer in a subject, the method comprising:

• sequencing a nucleic acid found in a normal cell of a subject, thereby obtaining a wild-type sequence;
• sequencing a nucleic acid found in a cancerous or pre-cancerous cell of the subject, thereby obtaining a mutated sequence;
• comparing the wild-type sequence and the mutated sequence, thereby determining a difference between the wild-type sequence and the mutated sequence;
• administering to the subject a first nucleic acid probe coupled to a prodrug of a chemotherapeutic agent and a second nucleic acid probe coupled to an activating agent;
• wherein the probes hybridize to a first portion and a second portion that are identical in both the wild-type sequence and the mutated sequence;
• wherein the first and second portions in the wild-type sequence are not within sufficient proximity of each other for the activating agent to convert the prodrug to an active form of the chemotherapeutic agent;
• and
• wherein the first and second portions in the mutated sequence are within sufficient proximity of each other for the activating agent to convert the prodrug to an active form of the chemotherapeutic agent, thereby providing targeted delivery of the chemotherapeutic agent to the cancerous or pre-cancerous cell in the subject.