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US 8,575,120 B2Granted
Genetic alterations on chromosome 12 and methods of use thereof for the diagnosis and treatment of type 1 diabetes
AssigneeThe Children's Hospital of Philadelphia
InventorsHakon Hakonarson, Struan F. A. Grant, Jonathan P. Bradfield, Constantin Polychronakos
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Abstract
Compositions and methods for the detection and treatment of T1D are provided.
Claims3
A method for identifying a combination of siRNA molecules selected from the group disclosed Tables 5-10 effective for down-regulating the expression of at least one protein selected from the group consisting of RAB5B, CDK2, SUOX, IKZF4, RPS26 and ERBB3, comprising:
- a) contacting a cell with an effective amount of at least two siRNA molecules selected from the group disclosed in Tables 5-10;
- b) assessing the effect of said siRNAs on down regulation of at least RPS26 expression relative to untreated cells.
Dependencies are inferred from the claim text.