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US 8,575,116 B1Granted
Polyacetylenic compounds for protecting against pancreatic islet atrophy
AssigneeAcademia Sinica
InventorWen-Chin Yang
Life of this patent
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Abstract
Pharmaceutical compositions and methods for protecting against atrophy of pancreatic islets in a human with metabolic syndromes are disclosed. The method comprises administering to the mammal a pharmaceutical composition comprising a compound having a chemical structure of formula (I) in an effective amount and a pharmaceutically acceptable carrier: wherein R is H or COCH2COOH; m=3 or 4; n=0 or 1; o=2; and p=1 or 2.
Claims11
A method of protecting against atrophy of pancreatic islets, comprising:
- administering a pharmaceutical composition comprising:
- (a) an effective amount of a compound of formula (I)
- wherein
- R is H or COCH2COOH;
- m=3 or 4;
- n=0 or 1;
- o=2;
- and
- p=1 or 2, and
- (b) a pharmaceutically acceptable carrier;
- to a human who has any three of the following conditions:
- i) waist measurement of 40 inches or more for men and 35 inches or more for women;
- ii) triglyceride levels of 150 milligrams per deciliter (mg/dL) or above, or taking medication for elevated triglyceride levels;
- iii) HDL cholesterol level below 40 mg/dL for men and below 50 mg/dL for women, or taking medication for low HDL levels;
- and
- iv) blood pressure levels of 130/85 or above, or taking medication for elevated blood pressure levels.
13 more elements
Dependencies are inferred from the claim text.