Peptidic nanoparticles as drug delivery and antigen display systems

A peptidic nanoparticle consisting of an assembly of 10 or more peptides, in which each peptide is consisting of a continuous chain of a peptidic oligomerization domain D1, a linker segment L, and a peptidic oligomerization domain D2 of formula (I):

• D1-L-D2 (I),
• wherein
• each D1 is a synthetic or natural peptide, and a plurality of D1 form at least one protein oligomer assembly (D1)m, wherein the protein oligomer assembly consists of m subunits of D1,
• each D2 is a synthetic or natural peptide, and a plurality of D2 form at least one protein oligomer assembly (D2)n, wherein the protein oligomer assembly consists of n subunits of D2,
• the peptidic nanoparticle contains:
• (a) one of m or n is 2 forming a dimer protein oligomer assembly, and the other of m or n is 5 forming a pentamer protein oligomer assembly;
• or
• (b) one of m or n is 3 forming a trimer protein oligomer assembly, and the other of m or n is 4 or 5 forming a tetramer or pentamer protein oligomer assembly, respectively;
• or
• (c) one of m or n is 4 forming a tetramer protein oligomer assembly, and the other of m or n is 5 forming a pentamer protein oligomer assembly;
• L is a short flexible linker segment,
• at least one D1 or D2 is a coiled-coil peptide sequence, and
• D1, D2 or L is optionally further substituted by a substituent selected from a targeting entity, drug and antigen.