US 8,575,103 B2Granted

Peptides and methods for inhibiting G alpha protein signaling

AssigneeThe Board of Trustees of the University of Illinois

InventorsGuy Le Breton, Jin-Sheng Huang, Subhashini Srinivasan, Fadi T. Khasawneh

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Abstract

Permeable Switch Region I and II peptides in the range of 9 to 25 amino acid residues in length are provided for specifically inhibiting signaling through Gα subunits. In addition, compositions and methods for inhibiting platelet aggregation and α11bβ3 integrin activation using the Switch Region I and II peptides are provided.

Claims4

Dependent claims

A Gα peptide, wherein said Gα peptide consists of SEQ ID NO:

2-5, 11-22 or 24-34.

Dependencies are inferred from the claim text.

Facts

Application: 13/425,922Filed 21 Mar 2012 · continuation in part
Priority: 24 Sep 2009
Published: US 2013/0040886 A114 Feb 2013
Granted: 5 Nov 2013
Term ends: Not estimatedThe source records don’t support an estimate.

Classification4 codes

A61K 38/10
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof: peptides having 12 to 20 amino acids
A61P 7/02
Drugs for disorders of the blood or the extracellular fluid: antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
A61K
Medicines and medical preparations
A61P
Therapeutic uses of medicines

Family

Application61/245,389Us provisional application · filed 24 Sep 2009
Application61/350,093Us provisional application · filed 1 Jun 2010
PCT/US2010/049905Parent of this continuation-in-part · filed 23 Sep 2010
US 2013/0040886 A1Pre-grant publication · published 14 Feb 2013
US 8,575,103 B2This patent

From the US filing history. Foreign family members aren’t listed.

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