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US 8,575,102 B2Granted
Conjugates having a releasable linkage
AssigneeNektar Therapeutics
InventorsSean M. Culbertson, Samuel P. McManus, Mary J. Bossard
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Abstract
The present invention provides conjugates encompassed by the following structure, wherein: D is a residue of an active agent bearing at least one amino group; and PEG-m is a methoxy end-capped poly(ethylene glycol), and further wherein the active agent is a coagulation factor having a molecular weight of greater than 100 kDa. Methods of making conjugates, and methods for administering conjugates, are also provided.
Claims9
A compound having the following structure:
- wherein:
- D is a residue of an active agent bearing at least one amino group;
- and;
- PEG-m is a methoxy end-capped poly(ethylene glycol), and further wherein the active agent is a coagulation factor having a molecular weight of greater than 100 kDa.
1 more element
Dependencies are inferred from the claim text.