Back to results
US 8,575,095 B2Granted
Active cores of peptide triazole HIV-1 entry inhibitors
AssigneePhiladelphia Health and Education Corporation
InventorsIrwin M. Chaiken, Umashankara Muddegowda, Karyn McFadden
Life of this patent
Estimating the term…
Abstract
The invention provides a peptide triazole conjugate and derivatives thereof, and methods of its use. Further provided are an antibody to the peptide triazole conjugate, and a method of identifying an HIV-1 entry inhibitor candidate.
Claims31
A peptide triazole conjugate comprising a peptide component comprising the sequence X1X2X3NIPWX4 (SEQ ID No. 3),
- wherein X1 is absent or E, wherein
- X2 is F, K, E, R and Cit;
- wherein X3 is N or I;
- wherein X4 is S or T;
- wherein the proline in SEQ ID No. 3 is modified according to Formula I:
- wherein R is a bulky aromatic group.
3 more elements
The pharmaceutical composition of 7, wherein R of the peptide triazole conjugate is ferrocene.
Dependencies are inferred from the claim text.