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US 8,574,914 B2Granted
Methods for mobile zinc measurement
AssigneesThe General Hospital Corporation, Massachusetts Institute of Technology
InventorsStephen J. Lippard, Xiao-an Zhang, Zdravka Medarova, Anna Moore
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Abstract
This invention relates to a method for using a zinc sensor compound to detect a disease associated with the disruption of zinc homeostasis, such as prostate cancer. The zinc sensor compound comprises an optical reporter having two or more recognition units where each of the recognition units is capable of associating with at least one zinc ion.
Claims21
An assay for measuring zinc in a biological sample comprising:
- exposing a biphasic zinc sensor compound to the biological sample obtained from a subject, wherein the zinc sensor compound comprises a fluorophore reporter having two or more recognition units, wherein each of the recognition units is capable of associating with at least one zinc ion, and wherein the zinc sensor compound exhibits a biphasic response to the presence of zinc ions;
- and
- measuring fluorescence of the fluorophore reporter of the zinc sensor compound after the fluorophore reporter has been exposed to the biological sample,
- wherein a difference in the measurement between the biological sample and a reference is indicative of the subject having or being at risk of a disease associated with a disruption of zinc homeostasis.
1 more element
Dependencies are inferred from the claim text.