Back to results
US 8,574,903 B2Granted
Method for expanding monocytes
AssigneeInserm (Institut Natuonal de la Santa et de la Recherche Medicale)
InventorMichael Sieweke
Life of this patent
Estimating the term…
Abstract
The invention relates to an ex vivo method for expanding monocytes, macrophages or dendritic cells, which method comprises inhibiting the expression or the activity of MafB and c-Maf in monocytes, macrophages or dendritic cells; and expanding the cells in the presence of at least one cytokine or an agonist of cytokine receptor signaling.
Claims8
An ex vivo method for expanding monocytes, macrophages or dendritic cells, which method comprises inhibiting the expression or the activity of MafB and c-Maf in monocytes, macrophages or dendritic cells;
- and expanding the cells in the presence of at least one cytokine, wherein the at least one cytokine comprises an agonist of M-CSF receptor signaling;
- and wherein said inhibition of both MafB and c-Maf in said cell renders said cell a self-renewing cell in culture.
Dependencies are inferred from the claim text.