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AssigneeOno Pharmaceutical Co., Ltd.
InventorsNagahiro Minato, Yoshimasa Tanaka, Shiro Shibayama
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As a substance which pharmacologically regulates the function of a cell surface functional molecule, a substance which has specificity and an activity or efficacy equal or superior to an antibody and does not require an advanced production technique and facility for application thereof to a pharmaceutical product has been demanded. The invention relates to a multimer of an extracellular domain of a cell surface functional molecule, particularly a tetramer of an extracellular domain of PD-1 or PD-L1. Further, the invention relates to an application of such a tetramer as a preventive and/or therapeutic agent for cancer, cancer metastasis, immunodeficiency, an infectious disease or the like and an application of PD-1 or PD-L1 as a testing or diagnostic agent or a research agent for such a disease.
A multimer comprising 2 to 10 extracellular domains of Programmed Cell Death-Ligand 1 (PD-L1), wherein the extracellular domains of PD-L1 are serially-concatenated directly or with peptide linkers, and wherein said PD-L1 is human PD-L1 or mouse PD-L1,
The multimer according to 2to 10 extracellular domains of Programmed Cell Death-Ligand (PD-L1) wherein the extracellular of PD-L1 are bound to a carrier via a non-peptide linker, and wherein said PD-L1 or mouse PD-L1,
Dependencies are inferred from the claim text.