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US 8,574,858 B2Granted
Autoantibody enhanced immunoassays and kits
AssigneeAbbott Laboratories
InventorsMaciej Adamczyk, Roy Jeffrey Brashear, Phillip G. Mattingly
Life of this patent
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Abstract
The present disclosure provides immunoassays and kits for detection or quantification of an analyte of interest in a test sample that potentially contains endogenously produced autoantibodies reactive with the analyte.
Claims13
An immunodetection composition comprising:
- a) a first detection complex comprising a first antibody reactive with an analyte of interest and bound to a solid phase, the analyte of interest, and a second antibody reactive with the analyte of interest, wherein the second antibody has a detectable label;
- and
- b) a second detection complex comprising an autoantibody reactive with the analyte of interest and bound to the solid phase, the analyte of interest, and the second antibody,
- wherein the first and second complexes generate a measurable optical, electrical, or change-of-state signal from the detectable label.
1 more element
Dependencies are inferred from the claim text.