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US 8,574,851 B2Granted
Prediction and prevention of preeclampsia
AssigneesCorthera, Inc., University of Pittsburgh—Of the Commonwealth System of Higher Education, University of Florida Research Foundation, Inc.
InventorsDennis Stewart, Kirk P. Conrad, Arundhathi Jeyabalan
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Abstract
The present disclosure relates to methods for detecting an increased risk of preeclampsia, determining the presence of preeclampsia, reducing the likelihood that preeclampsia will develop and treating preeclampsia. It also provides methods of measuring relaxin levels in a biological sample of a pregnant woman.
Claims5
A method of assessing whether a pregnant woman has an increased risk of developing preeclampsia, comprising:
- a) obtaining a sample of plasma or serum from a woman during week 5-15 of pregnancy;
- b) measuring the H2 relaxin concentration in the plasma or serum by immunoassay;
- and
- b) determining that said pregnant woman has an increased risk of developing preeclampsia when said H2 relaxin concentration is less than about 500 pg/ml,
- wherein an H2 relaxin concentration of less than about 500 pg/ml is an independent risk factor for preeclampsia.
2 more elements
Dependencies are inferred from the claim text.