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US 8,574,829 B2Granted
Methods of treating cancer with phenformin
AssigneeThe Trustees of the University of Pennsylvania
InventorsCraig B. Thompson, Roland Knoblauch
Life of this patent
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Abstract
Methods of using phenformin to treat certain types of cancers are described.
Claims16
A method of treating cancer in a patient comprising
- assaying the cancer for at least one of p53 deficiency, over-expression of c-myc, Bax-deficiency, Bak-deficiency, and glutamine dependence;
- and
- in response to a positive assay for at least one of p53 deficiency, over-expression of c-myc, Bax-deficiency, Bak deficiency, and glutamine dependence,
- administering to the patient a therapeutically effective amount of phenformin.
1 more element
A method for adjusting the chemotherapeutical treatment of a neoplasm in a patient comprising
- assaying the neoplasm for at least one of p53 deficiency, over-expression of c-myc, Bax-deficiency, Bak-deficiency, and glutamine dependence;
- and
- in response to a positive assay for at least one of p53 deficiency, over-expression of c-myc, Bax-deficiency, Bak deficiency, and glutamine dependence
- administering to the patient a therapeutically effective amount of phenformin;
- and
- in response to a negative assay for at least one of p53 deficiency, over-expression of c-myc, Bax-deficiency, Bak-deficiency, and glutamine dependence, refraining from administering to the patient a therapeutically effective amount of phenformin.
3 more elements
Dependencies are inferred from the claim text.