US 8,574,634 B2 · Compositions and methods of treatment with proanthocyanidin polymer antidiarrheal compositions

Abstract

Pharmaceutical compositions containing a proanthocyanidin polymer composition which are useful for the treatment and prevention of secretory diarrhea are provided. The invention specifically relates to pharmaceutical formulations of a proanthocyanidin polymer composition which has been isolated from a Croton spp. or a Calophyllum spp. In particular, the invention relates to a formulation of a proanthocyanidin polymer composition which protects the composition from the effects of stomach acid after oral administration, particularly to those formulations which are enteric coated. The invention also relates to methods of producing a directly compressible proanthocyanidin polymer composition, as well as compositions containing the directly compressible proanthocyanidin polymer composition.

Claims16

Dependent claims

A method of treating secretory diarrhea in an animal, comprising:

orally administering, to the animal, an enteric coated pharmaceutical composition comprising a therapeutically effective amount of an aqueous soluble proanthocyanidin polymer composition isolated from a Croton species or a Calophyllum species, and a pharmaceutically acceptable carrier.

Dependencies are inferred from the claim text.

Facts

Application

12/175,131Filed 17 Jul 2008 · continuation

Priority

16 Oct 1996

Published

US 2009/0148397 A111 Jun 2009

Granted

5 Nov 2013

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

A61K 31/353
Condensed with carbocyclic rings, e.g. methantheline: 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
A61K 9/2846
Obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone: polyacrylates
A61K 9/5078
Having two or more different coatings optionally including drug-containing subcoatings: with drug-free core
A61K 31/765
Synthetic polymeric materials: polymers containing oxygen

Family

Application08/730,772Parent of this continuation-in-part · filed 16 Oct 1996

Application09/066,989Parent of this continuation · filed 23 Apr 1998

Application09/712,033Parent of this continuation · filed 14 Nov 2000

Application11/998,171Parent of this continuation · filed 28 Nov 2007

US 7,341,744 B1Parent of this continuation · filed 11 Mar 2008

US 2009/0148397 A1Pre-grant publication · published 11 Jun 2009

Application09/066,989Parent of this continuation-in-part

US 8,574,634 B2This patent

From the US filing history. Foreign family members aren’t listed.

Compositions and methods of treatment with proanthocyanidin polymer antidiarrheal compositions

Life of this patent

Compositions and methods of treatment with proanthocyanidin polymer antidiarrheal compositions

Life of this patent

Abstract

Claims16