Tablet dosage form
AssigneeWockhardt Limited
InventorsGirish Kumar Jain, Ramakant Gundu, Rahul Dabre
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Abstract
The present invention relates to novel tablet dosage forms and methods of preparing these forms, which can be used for different classes of pharmaceutical active ingredients posing stability issues in a single unit system. The dosage form includes a first layer, which includes a tablet of one or more active pharmaceutical ingredients, which is inlayed in the first layer along with other pharmaceutically acceptable excipients, and a second layer that includes one or more active pharmaceutical ingredients optionally with other pharmaceutically acceptable excipients.
Claims1
The pharmaceutical composition comprising the following:
- S.
- %
- No.
- Ingredients
- Composition
- Misoprostol blend layer Misoprostol:hypromellose (1:100)
- Misoprostol
- 0.01 to 2.0
- Hypromellose
- 10 to 99
- Crospovidone
- 1 to 10
- Colloidal Silicon dioxide
- 0.1 to 10
- Microcrystalline cellulose
- 10 to 90
- Hydrogenated castor oil
- 0.1 to 2.0
- Diclofenac sodium tablets in inert excipients layer
- Diclofenac sodium
- 5 to 70
- Microcrystalline cellulose
- 10 to 90
- Lactose
- 10 to 90
- Sodium Starch glycolate
- 1 to 10
- Povidone
- 1 to 10
- Magnesium stearate
- 0.1 to 5
- Seal Coating
- Hypromellose + PEG 400
- 1 to 5
- Purified water
- q.s.
- Enteric Coating
- Methacrylic acid co-polymer suspension
- 8 to 25
- (Methacrylic acid copolymer, sodium
- hydroxide, talc, triethyl citrate, purified
- water)
- Inert Excipients
- Crospovidone
- 1 to 10
- Microcrystalline cellulose
- 10 to 80
- Colloidal Silicon dioxide
- 0.1 to 10
- Hydrogenated castor oil
- 0.1 to 2.0.
Dependencies are inferred from the claim text.