Surgical grafts for repairing chondral defects
OwnerHwa-Chang Liu, Feng-Huei Lin +2inventors
InventorsHwa-Chang Liu, Feng-Huei Lin, Shing-Mou Lee, Chun-Che Yen
Life of this patent
Estimating the term…
Abstract
An implant containing a collagen matrix embedded with chondrocyte-like cells, its use in repairing a chondral defect, and a method of preparing the implant.
Claims17
A method for repairing a chondral defect in a patient comprising:
- providing an implant containing a collagen matrix embedded with chondrocyte-like cells, the chondrocyte-like cells being differentiated from mesenchymal stem cells (MSCs) and being glycosaminoglycan-secreting, and
- placing the implant in the patient at a chondral defect site;
- wherein the implant is free of lacunae and is prepared by cultivating the MSCs for 7 to 20 days in a collagen-containing medium supplemented with transforming growth factor beta one (TGF-β1) under conditions allowing differentiation of the MSCs to the chondrocyte-like cells and formation of the implant.
An implant for repairing a chondral defect, comprising a collagen matrix embedded with chondrocyte-like cells, wherein the implant, free of lacunae, is prepared by cultivating mesenchymal stem cells (MSCs) for 7 to 20 days in a collagen-containing medium supplemented with transforming growth factor beta one (TGF-β1) under conditions allowing differentiation of the MSCs to the chondrocyte-like cells and formation of the implant, the chondrocyte-like cells being glycosaminoglycan-secreting.
Dependencies are inferred from the claim text.