Medical devices having a coating of biologic macromolecules
AssigneeBoston Scientific Scimed, Inc.
InventorPeter Edelman
Life of this patent
Estimating the term…
Abstract
A medical device having a coating of biologic macromolecules. The coating of biologic macromolecules is protected by a temporary protective layer disposed over the biologic macromolecules. The temporary protective layer serves to protect the structure (e.g., conformation) and/or function (e.g., target binding capacity) of the biologic macromolecules during processing, storage, handling, and/or delivery (e.g., implantation or insertion into a patient) of the medical device. Upon implantation or insertion into a patient's body, the temporary protective layer may dissolve to expose the biologic macromolecules to the physiologic environment.
Claims14
A medical device having a coating, the coating comprising:
- biologic macromolecules disposed over a surface of the medical device, wherein the biologic macromolecules are capable of binding endothelial cells;
- and
- a temporary protective layer disposed over at least a portion of the biologic macromolecules, the temporary protective layer comprising a water-soluble low molecular weight carbohydrate, and wherein the temporary protective layer substantially dissolves within 24 hours after implantation or insertion of the medical device in a patient.
A medical device having a coating, the coating comprising:
- a monolayer of antibodies disposed over a surface of the medical device, wherein the antibodies are directed to a cell surface component of endothelial cells;
- and
- a temporary protective layer disposed over at least a portion of the monolayer of antibodies, the temporary protective layer comprising a monosaccharide or a disaccharide, and wherein the temporary protective layer substantially dissolves within 6 hours after implantation or insertion of the medical device in a patient.
Dependencies are inferred from the claim text.