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US 8,574,604 B2Granted
Methods and compositions for the delivery of biologically active agents
AssigneeInterface Biologics, Inc.
InventorsRoseita Esfand, Paul J. Santerre, Meilin Yang
Life of this patent
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Abstract
The invention features polymers noncovalently complexed with a biologically active agent. The polymer complexes include at least one shielding moiety covalently tethered to at least one complexing moiety, which is complexed with at least one biologically active agent.
Claims24
A polymer described by the formula:
- FT−LINK A[−(oligo)a−(LINK A)b]c−Td(Bio)e,
- wherein
- FT is a polyfluoroorgano group;
- Bio is one or more biologically active agents capable of being complexed to LINK A;
- each LINK A is, independently, an organic moiety comprising a complexing moiety that is tri-hydroxymethyl aminoethane (Tris);
- oligo is an oligomeric segment;
- T is a terminal group;
- a is 0 or 1;
- b, c, d, and e are integers greater than 0;
- and
- wherein at least one Bio is complexed via hydrogen bonding interactions to at least one LINK A, and
- wherein each Bio is selected from the group consisting of antibiotics, antiproliferative agents, rapamycin macrolides, analgesics, anesthetics, antiangiogenic agents, antithrombotic agents, vasoactive agents, anticoagulants, immunomodulators, cytotoxic agents, antiviral agents, psychoactive drugs, vitamins, lipids, and prodrugs thereof.
9 more elements
Dependencies are inferred from the claim text.