Immunogenic compositions for the prevention and treatment of meningococcal disease
AssigneeWyeth
InventorGary Warren Zlotnick
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Abstract
The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.
Claims25
An isolated polypeptide comprising
- the amino acid sequence set forth in any of the even numbered sequences of SEQ ID NOS:2-12.
An isolated polypeptide prepared by a process comprising isolating and purifying from Neisseria meningitidis or recombinantly preparing any of:
- (a) a polypeptide comprising the amino acid sequence of any of even numbered SEQ ID NOS:
- 2-12 or
- (b) a polypeptide encoded by a polynucleotide comprising the nucleic acid sequence of any of odd numbered SEQ ID NOS:
- 1-11.
An isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 12.
An immunogenic composition comprising an isolated polypeptide having the amino acid sequence set forth in SEQ ID NO:
- 12.
Dependencies are inferred from the claim text.