KDR peptides and vaccines comprising the same
AssigneeOncotherapy Science, Inc.
InventorsHideaki Tahara, Satoshi Wada, Takuya Tsunoda
Life of this patent
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Abstract
The present invention provides nonapeptides selected from peptides comprising the amino acid sequence of SEQ ID NO:2, 3, 5, 8, 11, or 12; nonapeptides or decapeptides selected from peptides comprising the amino acid sequence of SEQ ID NO:29, 30, 33, 34, 40, or 46; and peptides with cytotoxic T cell inducibility, in which one, two, or several amino acids are substituted or added to the above-mentioned amino acid sequences, as well as pharmaceuticals for treating or preventing tumors, where the pharmaceuticals comprise these peptides. The peptides of this invention can be used as vaccines.
Claims5
A method of treating tumors in a subject comprising administering to the subject one or more peptides of any one of (a) to (e):
- (a) a nonapeptide consisting of the amino acid sequence of SEQ ID NO:
- 30,
- (b) a peptide with cytotoxic T cell inducibility, wherein zero, one or two amino acids are substituted to the amino acid sequence of SEQ ID NO:
- 30, and the peptide binds to an HLA-A0201 restricted T cell receptor with high affinity and induces a high CTL response,
- (c) the peptide of (b), wherein the second amino acid from the N terminus is leucine or isoleucine,
- (d) the peptide of (c), wherein the peptide consists of the amino acid sequence of SEQ ID NO:
- 54, and
- (e) the peptide of (b) or (c), wherein the C-terminal amino acid is leucine.
A method of inhibiting angiogenesis at a diseased site in a subject comprising administering to the subject a composition comprising a peptide of any one of (a) to (e) as an active ingredient:
- (a) a nonapeptide consisting of the amino acid sequence of SEQ ID NO:
- 30,
- (b) a peptide with cytotoxic T cell inducibility, wherein zero, one or two amino acids are substituted to the amino acid sequence of SEQ ID NO:
- 30, and the peptide binds to an HLA-A0201 restricted T cell receptor with high affinity and induces a high CTL response,
- (c) the peptide of (b), wherein the second amino acid from the N terminus is leucine or isoleucine,
- (d) the peptide of (c), wherein the peptide consists of the amino acid sequence of SEQ ID NO:
- 54, and
- (e) the peptide of (b) or (c), wherein the C-terminal amino acid is leucine.
Dependencies are inferred from the claim text.