Anti-IL-23 antibodies
AssigneeJanssen Biotech, Inc.
InventorsJacqueline Benson, Mark Cunningham, Cynthia Duchala, Jill M. Giles-Komar, Jinquan Luo, Michael A. Rycyzyn, Sweet Raymond
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Abstract
An anti-IL-23 antibody, including isolated nucleic acids that encode at least one anti-IL-23 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
Claims13
An isolated IL-23p19 antibody fragment, wherein said antibody fragment binds to human IL-23p19 at one or more regions of human IL-23p19 consisting of the amino acid residues selected from the group consisting of residues 93-102, 93-110, and 127-137 of SEQ ID NO:1.
An isolated IL-23p19 antibody fragment, comprising a light chain variable region comprising:
- a complementarity determining region light chain 1 (CDRL1) amino acid sequence of SEQ ID NO:9;
- a CDRL2 amino acid sequence of SEQ ID NO:10;
- and
- a CDRL3 amino acid sequence of SEQ ID NO:11,
- or a heavy chain variable region comprising:
- a complementarity determining region heavy chain 1 (CDRH1) amino acid sequence of SEQ ID NO:4;
- a CDRH2 amino acid sequence of SEQ ID NO:5;
- and
- a CDRH3 amino acid sequence of SEQ ID NO:6.
Dependencies are inferred from the claim text.