Methods and compositions for modulating wound repair
AssigneesWomen's & Children's Health Research Institute Inc., Adelaide Research & Innovation Pty Ltd, The Australian National University
InventorsAllison June Cowin, Hugh Douglas Campbell, Barry Powell
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Abstract
The present invention relates to a method of modulating repair of a wound. The method includes modulating expression and/or activity of Flightless I in cells involved in repair of the wound.
Claims9
A method of improving repair of a skin wound in a subject, the method including administering to the subject an effective amount of an agent that decreases activity of Flightless I in one or more cells of the subject involved in repair of the wound to thereby improve repair of the wound, wherein the agent is a neutralizing antibody to Flightless I, or an antigen binding part of a neutralizing antibody to Flightless I.
A method of reducing scar formation in a skin wound of a subject, the method including the step of delivering to the wound an effective amount of an agent that decreases activity of Flightless I and thereby reduces scar formation in the wound, wherein the agent is a neutralizing antibody to Flightless I, or an antigen binding part of a neutralizing antibody to Flightless I.
A method of decreasing one or more of expression, secretion and/or activity of TGF-β1 and/or decreasing secretion of collagen I in a cell of a subject, the method including administering to the subject an agent to decrease activity of Flightless I in the cell to thereby decrease one or more of expression, secretion and/or activity of TGF-β1 and/or decrease secretion of collagen I in the cell, wherein the agent is a neutralizing antibody to Flightless I, or an antigen binding part of a neutralizing antibody to Flightless I, and wherein the cell is a cell involved in skin wound repair and/or scar formation in a skin wound.
A method of increasing migration and/or proliferation of a cell involved in skin wound repair or scar formation in a skin wound in a subject, the method including delivering an effective amount of an agent that decreases activity of Flightless I to cells in the subject involved in repair of the wound or scar formation to thereby increase migration and/or proliferation of the cell, wherein the agent is a neutralizing antibody to Flightless I, or an antigen binding part of a neutralizing antibody to Flightless I.
A method according to 7, wherein the cell is a fibroblast or a keratinocyte.
Dependencies are inferred from the claim text.