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US 8,574,569 B2Granted
Stabilized protease composition
AssigneeTrobio AB
InventorsLars-Olov Andersson, Hans Ageland
Life of this patent
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Abstract
A composition is provided, which comprises a serine protease; a reversible inhibitor of said serine protease; and a stabilizing agent M having the formula I: Also provided are uses of the composition as a medicament, and other uses and methods employing its various properties.
Claims18
A stabilized serine protease composition comprising an aqueous solution of
- a) thrombin;
- b) a reversible inhibitor of thrombin which exhibits a Ki value of between 0.01 and 2 mM;
- and
- c) a stabilizing agent M, wherein M is 3-(N-morpholino)propane sulfonic acid and M is present in a concentration in the range of 0.1-0.3 M.
1 more element
A stabilized serine protease composition comprising an aqueous solution of
- a) thrombin, wherein said thrombin is present in a concentration of 0.001-2 mg/ml;
- b) a reversible inhibitor of thrombin, wherein said reversible inhibitor of thrombin is present in a concentration of 0.1-10 mM;
- and
- c) a stabilizing agent M, wherein M is 3-(N-morpholino)propanesulfonic acid and M is present in a concentration in the range of 0.1-0.3 M.
1 more element
Dependencies are inferred from the claim text.