Pharmaceutical composition to protect an animal against a disorder arising from an infection with a bacterium that belongs to the group of nocardioform actinomycetes
AssigneeIntervet International B.V.
InventorsAntonius Arnoldus Christiaan Jacobs, Robert Van Der Geize, Lubbert Dijkhuizen
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Abstract
The invention pertains to a pharmaceutical composition to protect an animal against a disorder arising from an infection with a bacterium that belongs to the group of nocardioform actinomycetes having the ability to survive within macrophages of the animal, comprising live bacteria of a nocardioform actinomycetes species, the live bacteria being attenuated by inactivation of a gene that encodes a protein involved in methylhexahydroindanedione propionate degradation, and a pharmaceutically acceptable carrier for these live bacteria.
Claims3
A Rhodococcus equi bacterium derived from a strain as deposited with the Collection Nationale de Cultures de Micro-organismes of the Institut Pasteur at Paris France under nr. CNCM I-4108 or nr. CNCM I-4109.
A Rhodococcus equi bacterium of a strain as deposited with the Collection Nationale de Cultures de Micro-organismes of the Institut Pasteur at Paris France under nr. CNCM I-4108 or nr. CNCM I-4109.
A method of treating an animal to protect it against a disorder arising from an infection with a bacterium that belongs to the group of nocardioform actinomycetes having the ability to survive within macrophages of an animal, comprising administering to the animal a pharmaceutical composition comprising live bacteria of a nocardioform actinomycetes species, which live bacteria are attenuated by inactivation of a gene that encodes a protein involved in methylhexahydroindanedione propionate degradation.
Dependencies are inferred from the claim text.