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US 8,574,562 B2Granted
Microemulsion pharmaceutical composition comprising a macrolide immunosuppressant drug
AssigneeNovaliq GmbH
InventorAlexandra Sabine Baerbel Goebel
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Abstract
The invention provides novel pharmaceutical compositions of macrolide immunosuppressants. The compositions comprise a hydrophilic component, a lipophilic component, and an amphiphilic component. Preferably, the compositions are formulated as liquid microemulsion. Furthermore, the invention provides uses of such compositions, such as for the topical treatment of inflammatory and autoimmune diseases. Methods for preparing the compositions are also provided.
Claims12
A pharmaceutical composition comprising:
- a therapeutically active ingredient selected from the group consisting of sirolimus, everolimus, tacrolimus, pimecrolimus, ridaforolimus, temsirolimus, and zotarolimus,
- a hydrophilic component;
- a lipophilic component;
- and
- an amphiphilic component,
- wherein the composition is formulated as a microemulsion;
- and
- wherein the hydrophilic component comprises a combination of water and a liquid glycol which is preferably selected from glycerol, propylene glycol, 1,2-pentylene glycol, and polyethylene glycol, further characterized in that the ratio of water to the liquid glycol is in the range from about 1:10 to about 10:1.
5 more elements
Dependencies are inferred from the claim text.