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AssigneeKorea Research Institute of Bioscience and Biotechnology
InventorsWon Gon Kim, Chang Ji Zheng, Ki Young Kim, Mi Jin Sohn
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The present invention relates to an antibacterial pharmaceutical composition comprising an Aceriphyllum rossii extract, and aceriphyllic acid A and 3-oxo-12-oleanen-27-oic acid isolated therefrom. The Aceriphyllum rossii extract of the present invention, and aceriphyllic acid A and 3-oxo-12-oleanen-27-oic acid isolated therefrom have strong antibacterial activities against Staphylococcus aureus, methicillin-resistant S. aureus, quinolone-resistant S. aureus, Acinetobacter calcoaceticus, Micrococcus luteus, Bacillus subtilis or Streptococcus mutans, Propionibacterium acnes, thereby being used for the prevention or treatment of pathogenic bacterial and resistant bacterial infections, cariogenic bacterial and acne bacterial infections.
A method of treating a bacterial infection in a subject in need of such treatment, the method comprising administering to the subject a composition comprising an effective amount of an Aceriphyllum rossii extract, wherein the bacterial infection is caused by one or more microorganisms selected from the group consisting of Staphylococcus aureus, methicillin-resistant S. aureus, quinolone-resistant S. aureus, Acinetobacter calcoaceticus, Micrococcus luteus, Bacillus subtilis, Streptococcus mutans, and Propionibacterium acnes.
A method of treating a bacterial infection in a subject in need of such treatment, the method comprising administering to the subject a composition comprising an effective amount of aceriphyllic acid A or 3-oxo-12-oleanen-27-oic acid, wherein the bacterial infection is caused by one or more microorganisms selected from the group consisting of Staphylococcus aureus, methicillin-resistant S. aureus, quinolone-resistant S. aureus, Acinetobacter calcoaceticus, Micrococcus luteus, Bacillus subtilis, Streptococcus mutans, and Propionibacterium acnes.
A method of treating a cariogenic bacterial infection in a subject in need of such treatment, the method comprising contacting an oral surface with an oral hygiene product comprising an effective amount of at least one substance selected from the group consisting of an Aceriphyllum rossii extract, aceriphyllic acid A and 3-oxo-12-oleanen-27-oic acid, wherein the cariogenic bacterial infection is caused by Streptococcus mutans.
Dependencies are inferred from the claim text.