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US 8,574,551 B2Granted
Compositions useful for reducing nephrotoxicity and methods of use thereof
AssigneeVerrow Pharmaceuticals, Inc.
InventorVernon D. Rowe
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Abstract
The present invention provides compositions and methods to reduce renal damage caused by nephrotoxic drugs. The invention provides compositions comprising an anionically substituted cyclodextrin, a nephrotoxic drug and a pharmaceutically acceptable carrier, where the cyclodextrin is present in an amount effective for substantially inhibiting the nephrotoxic effect of the drug.
Claims13
A method of inhibiting or reducing nephrotoxicity associated with an iodinated contrast agent, the method comprising:
- administering to a subject in need thereof a first pharmaceutical composition comprising an anionically substituted cyclodextrin of the formula:
- cyclodextrin-[(O—R—Y)−(Me)+]n
- where R is selected from the group consisting of straight chained or branched C1-10 alkyl, alkenyl or alkynyl;
- Y is an anionic group selected from COO, SO3, SO4, PO3H or PO4;
- Me is a pharmaceutically acceptable cation;
- and
- n is a whole number greater than 1, and
- administering to the subject a second pharmaceutical composition comprising an iodinated contrast agent selected from iohexyl, ioversol, diatrizoate meglumine and ioxaglate;
- wherein the molar ratio of agent:
- cyclodextrin is from 2:1 to 50:1.
7 more elements
Dependencies are inferred from the claim text.