US 8,573,198 B2 · Devices and methods for aerosol therapy using hyperbaric tonometry

Abstract

Methods and devices for creating a supersaturated liquid solution having dissolved gas with hyperbaric partial pressures and aerosolizing the supersaturated solution via a nebulizer. High partial pressures of the dissolved gas may be maintained before, during, and after the aerosolization process. Thus, the hyperbaric partial pressures may be retained in the aerosol particles even after the particles are exposed to ambient barometric pressure. The aerosolized particles may be inhaled to improve oxygenation and blood flow to the lung or alternatively, the aerosolized particles can be topically applied to accelerate wound healing. Nebulizers may produce aerosol particles in some embodiments have mass median aerodynamic diameters of between about 0.25 and about 5 microns, thereby allowing sufficient deposition in the lung parenchyma, proximal to alveoli. Supersaturated dissolved oxygen aerosol particles having mass median aerodynamic diameters greater than 10 microns may be used to accelerate wound healing when combined with ultrasound.

Claims22

Dependent claims

A method of aerosol therapy comprising:

forming in a non-pressurized vessel a non-blood liquid supersaturated with oxygen gas, the liquid being at a temperature below about 55° F. and at ambient atmospheric pressure;
transforming the liquid into aerosol particles that remain supersaturated with the oxygen gas, the aerosol particles remaining at a temperature below about 55° F.;
and
delivering the aerosol particles to the patient while the aerosol particles remain supersaturated with the oxygen gas.

1 more element

Dependencies are inferred from the claim text.

Devices and methods for aerosol therapy using hyperbaric tonometry

Life of this patent

Devices and methods for aerosol therapy using hyperbaric tonometry

Life of this patent

Abstract

Claims22