# US 8,571,662 B2 · Transvascular nerve stimulation apparatus and methods

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- Number: US 8,571,662 B2
- Document ID: US8571662B2
- Status: Granted
- Kind: B2
- Application number: 12/524,571
- Filed: 2008-01-29
- Published: 2010-02-11
- Granted: 2013-10-29
- Earliest claimed: 2007-01-29
- Assignees: Simon Fraser University
- Applicants: Joaquin Andres Hoffer
- Inventors: Joaquin Andres Hoffer
- Web page: https://patentgrep.com/patent/US8571662B2

## CPC

- A61N 1/3611: {Respiration control (stimulating respiratory organs A61N1/3601)}
- A61N 1/05: for implantation or insertion into the body, e.g. heart electrode (A61N1/06 takes precedence)
- A61N 1/0551: {Spinal or peripheral nerve electrodes}
- A61N 1/0558: {Anchoring or fixation means therefor}
- A61N 1/3601: {of respiratory organs}
- A61N 1/36139: {with automatic adjustment}
- A61N 1/36185: {Selection of the electrode configuration}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.

## Claims

### Claim 1

A method for regulating breathing of a person, the method comprising:
implanting at least one of: a first electrode structure at a position along a lumen of the left subclavian vein that is proximate to the left phrenic nerve; a second electrode structure at a position along a lumen of the superior vena cava that is proximate to the right phrenic nerve; a third electrode structure at a position along a lumen of the left interior jugular vein that is proximate to the left phrenic nerve; and a fourth electrode structure at a position along a lumen of the right interior jugular vein that is proximate to the right phrenic nerve;
stimulating at least one of the left- and right-phrenic nerves by applying stimulation signals to electrodes of the first and second electrode structures.

### Claim 2

A method for regulating breathing of a person, the method comprising:
implanting a first electrode structure at a position along a lumen of the left subclavian vein that is proximate to the left phrenic nerve;
implanting a second electrode structure at a position along a lumen of the superior vena cava that is proximate to the right phrenic nerve;
stimulating the left- and right-phrenic nerves by applying stimulation signals to electrodes of the first and second electrode structures.

### Claim 3 (depends on 2)

A method according to claim 2 comprising inserting the first and second electrode structures through a cannulation site in the person's left subclavian vein.

### Claim 4 (depends on 3)

A method according to claim 3 comprising inserting the first electrode structure and subsequently introducing the second electrode structure through a bore of the first electrode structure.

### Claim 5 (depends on 2)

A method according to claim 2, wherein the electrode structures each comprise an electrode supported on an electrically-insulating backing sheet; and, a structure for holding the backing sheet against the inner wall of a blood vessel with the electrode in contact with the inner wall of the blood vessel and the method comprises providing a balloon within the electrode structure and inflating the balloon to urge the backing sheet against an inner wall of the lumen of the blood vessel.