Method for simultaneously extracting the input function and pharmacokinetic parameters of an active ingredient

A non-transitory information storage medium comprising a code for simultaneously extracting the input function and pharmacokinetic parameters of an active ingredient in a structure of a living organism from a measurement image of the kinetics of the active ingredient in the structure obtained by an imaging device, the image comprising a plurality of regions of interest inside each of which the kinetics of the active ingredient are measured, wherein the code comprises instructions to:

• determine a plurality of sets of kinetics from the measured kinetics, the determined sets of kinetics being different from each other and each determined set of kinetics including several measured kinetics;
• define at least one kinetic model, parameters of the defined kinetic model being formed by parameters of an input function and pharmacokinetic parameters;
• estimate, for each determined set of kinetics, the input function and the pharmacokinetic parameters by resolving the kinetic model defined from the set of determined kinetics;
• and
• deduce a final input function and final pharmacokinetic parameters from estimated input functions and estimated pharmacokinetic parameters.

A device intended to simultaneously extract the input function and the pharmacokinetic parameters of an active ingredient in a structure of a living organism from a measurement image of the kinetics of the active ingredient in the structure obtained by an imaging device, the image comprising a plurality of regions of interest inside each of which the kinetics of the active ingredient are measured, comprising:

• an imaging device;
• and
• a data processing system connected to the imaging device and comprising:
• means for determining a plurality of sets of kinetics from measured kinetics, the determined sets of kinetics being different from each other and each determined set of kinetics including several measured kinetics;
• means for defining at least one kinetic model, parameters of the defined kinetic model being formed by parameters of an input function and pharmacokinetic parameters;
• means for estimating, for each determined set of kinetics, the input function and the pharmacokinetic parameters by resolving the defined kinetic model from the determined set of kinetics;
• and
• means for deducing a final input function and final pharmacokinetic parameters from estimated input functions and estimated pharmacokinetic parameters.