# US 8,570,027 B2 · High resolution scanning magnetic imaging method with long detection ranges

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- Number: US 8,570,027 B2
- Document ID: US8570027B2
- Status: Granted
- Kind: B2
- Application number: 12/791,763
- Filed: 2010-06-01
- Published: 2010-12-02
- Granted: 2013-10-29
- Earliest claimed: 2009-06-01
- Assignees: University of Houston System
- Applicants: Shoujun Xu; Li Yao
- Inventors: Shoujun Xu; Li Yao
- Web page: https://patentgrep.com/patent/US8570027B2

## CPC

- A61B 5/05: Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves (measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24)
- A61B 5/0515: Magnetic particle imaging
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A method of magnetic imaging at long detection ranges. In one embodiment the method comprises introducing a magnetic sample having magnetic particles into a detection field; detecting weak magnetic field signals of the magnetic particles; forming an image from the detected signals; and determining the location and quantity amount of the magnetic particles. The method further comprises introducing a magnetic sample to a human or other organism's body.

## Claims

### Claim 1

A method for scanning magnetic imaging which, comprising:
introducing a magnetic sample having magnetic particles into a detection field;
detecting weak magnetic field signals of the magnetic particles by moving the distance of the detector relative to the magnetic sample;
forming an image from the detected signals corresponding to the distance of the detector; and
determining the location and quantity amount of the magnetic particles.

### Claim 2 (depends on 1)

The method of claim 1, wherein the detection field comprises a scanning mode having at one operation chosen from the group consisting of: the sample is scanned in the vicinity of the detector, the detector is scanned in the vicinity of the sample, or combinations thereof.

### Claim 3 (depends on 2)

The method of claim 2, wherein the scanning comprises at least one component chosen from the group consisting of: translation stages, linear actuators, precision pumps, or combination thereof.

### Claim 4 (depends on 2)

The method of claim 2, wherein the scanning comprises a path chosen from the group consisting of: a straight line, a parabolic path, a curve, or combinations thereof.

### Claim 5 (depends on 2)

The method of claim 2, wherein the scanning is directed in the direction perpendicular to the propagation of laser along the x-axis and the z-axis, and parallel to the laser along the d-axis.

### Claim 6 (depends on 1)

The method of claim 1, wherein the detecting the weak field signals of the magnetic particles comprises a range from microns to centimeters.

### Claim 7 (depends on 6)

The method of claim 6 further comprises three-dimensional magnetic imaging with a scanning detector array.

### Claim 8 (depends on 6)

The method of claim 6, further comprising forming a profile of the weak magnetic field signals as a function of position in the x-axis and y-axis directions and the d-axis position.

### Claim 9 (depends on 1)

The method of claim 1, wherein the forming an image further comprises, constructing an image from a series of x-axis scanning profile of the magnetic sample at different d-distances relative to the magnetic detector.

### Claim 10 (depends on 1)

The method of claim 1, wherein the forming an image further comprises, constructing an image from a series of d-axis position in a scanning profile of the magnetic sample at different distances relative to magnetic detector.

### Claim 11 (depends on 1)

The method of claim 1, wherein determining the location and quantity amount of the magnetic particles further comprises, performing a least-square fit on the scanning profile of the magnetic field of the particles.

### Claim 12 (depends on 11)

The method of claim 11, wherein the least-square fit function is based on dipolar magnetic field.

### Claim 13 (depends on 1)

The method of claim 1, wherein the magnetic sample comprises at least one chose from the group consisting of magnetically-labeled chemicals, biochemicals, DNA, proteins, cells, and combinations thereof.

### Claim 14 (depends on 1)

The method of claim 1, further comprising positioning the magnetic samples in microchannels.

### Claim 15 (depends on 1)

The method of claim 1, further comprising detecting the magnetic samples in an organism body.

### Claim 16 (depends on 15)

The method of claim 15 wherein the magnetic samples are in a human body.