# US 8,569,514 B1 · Process for the preparation of strontium ranelate

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 8,569,514 B1
- Document ID: US8569514B1
- Status: Granted
- Kind: B1
- Application number: 13/603,896
- Filed: 2012-09-05
- Published: 2013-11-21
- Granted: 2013-10-29
- Earliest claimed: 2012-05-17
- Assignees: Divi's Laboratories, Ltd.
- Applicants: Murali Krishna Prasad Divi; Mysore Aswatha Narayana Rao; Shaik Nowshuddin
- Inventors: Murali Krishna Prasad Divi; Mysore Aswatha Narayana Rao; Shaik Nowshuddin
- Web page: https://patentgrep.com/patent/US8569514B1

## CPC

- C07D 333/40: Thiophene-2-carboxylic acid
- C07D 333/38: Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

Strontium ranelate is prepared by reacting dicyclohexylammonium ranelate with strontium halide in an anhydrous solvent. Strontium ranelate thus obtained will have less than 3% moisture content.

## Claims

### Claim 1

A process for the preparation of strontium ranelate having less than 3% moisture content which comprises:
a) reacting ranelic acid with dicyclohexylamine in an anhydrous solvent to obtain dicyclohexylammonium ranelate salt; and
b) reacting the dicyclohexylammonium ranelate salt with strontium halide in an anhydrous solvent to obtain strontium ranelate.

### Claim 2 (depends on 1)

The process according to claim 1, step-a, wherein the anhydrous solvent used is selected from the group consisting of ethers, esters, chlorinated hydrocarbons and ketones.

### Claim 3 (depends on 2)

The process according to claim 2, step-a, wherein the ether is methyl tert-butyl ether.

### Claim 4 (depends on 2)

The process according to claim 2, step-a, wherein the ester is ethyl acetate.

### Claim 5 (depends on 2)

The process according to claim 2, step-a, wherein the chlorinated hydrocarbon is dichloromethane.

### Claim 6 (depends on 2)

The process according to claim 2, step-a, wherein the ketone is acetone.

### Claim 7 (depends on 1)

The process according to claim 1, step-a, wherein the anhydrous solvent is selected from the group consisting of tetrahydrofuran and acetonitrile.

### Claim 8 (depends on 1)

The process according to claim 1, step-b, wherein the anhydrous solvent used is selected from the group consisting of alcohols and esters.

### Claim 9 (depends on 8)

The process according to claim 8, step-b, wherein the alcohol is methanol.

### Claim 10 (depends on 8)

The process according to claim 8, step-b, wherein the ester is butylformate.

### Claim 11 (depends on 1)

The process according to claim 1, step-b, wherein the anhydrous solvent is dimethylformamide.

### Claim 12 (depends on 1)

The process according to claim 1, step-b, wherein strontium halide used is strontium chloride.

### Claim 13 (depends on 12)

The process according to claim 12, wherein strontium chloride used has moisture content of less than 1%.

### Claim 14

Dicyclohexylammonium ranelate salt having dicyclohexylamine and ranelic acid in a ratio of 2:1.