Substituted 3-(1H-benzo[d]imidazol-2-yl)-1H-indazole analogs as inhibitors of the PDK1 kinase
AssigneeUniversity of Utah Research Foundation
InventorsDavid J. Bearss, Hariprasad Vankayalapati, Venkataswamy Sorna, Steven L. Warner, Sunil Sharma
Life of this patent
Estimating the term…
Abstract
In one aspect, the invention relates to substituted 3-(1H-benzo[d]imidazol-2-yl)-1H-indazole analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the PDK1 kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions for treating disorders associated with dysfunction of the PDK1 kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Claims17
A compound of structure(I):
- or a pharmaceutically acceptable salt thereof, wherein:
- L2 is —(C═O)— or —(CH2)q—,
- R7 is selected from hydrogen, halogen, cyano, C1-C6 alkyl and C3-C6 heterocycloalkyl;
- q is an integer from 1 to 3;
- and
- n is 0 or 1,
- wherein the C3-C6 heterocycloalkyl is selected from unsubstituted, monosubstituted, and geminally disubstituted morpholinyl;
- unsubstituted, monosubstituted and disubstituted piperidinyl;
- unsubstituted, monosubstituted and disubstituted aziridinyl;
- unsubstituted, monosubstituted and disubstituted piperazinyl;
- unsubstituted, monosubstituted and disubstituted hexahydropyrimidinyl;
- unsubstituted, monosubstituted and disubstituted hexahydropyridazinyl;
- unsubstituted, monosubstituted and disubstituted pyrrolidinyl;
- unsubstituted, monosubstituted and disubstituted oxazolidinyl;
- unsubstituted, monosubstituted and disubstituted imidazolidinyl;
- unsubstituted, monosubstituted and disubstituted pyrazolidinyl;
- unsubstituted, monosubstituted and disubstituted 1,3-oxazinanyl;
- unsubstituted, monosubstituted and disubstituted thiomorpholinyl 1,1-dioxide;
- and unsubstituted, monosubstituted and disubstituted 1-(C1-C6 alkylsulfonyl)piperazinyl;
- wherein the substituents, when present, are independently selected from halogen, cyano, C3-C6 cycloalkyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 polyhaloalkyl and an optionally substituted heterocycle selected from aziridinyl, piperazinyl, morpholinyl, pyrollidinyl, oxazolidinyl, imidazolidinyl, pyrazolidinyl, thiomorpholinyl 1,1-dioxide;
- and 1-(alkylsulfonyl)piperazinyl.
Dependencies are inferred from the claim text.