N-(2-oxo-1-phenylpiperidin-3-yl)sulfonamides for the identification of biological and pharmacological activity

A compound having formula (I)

• and the salts and stereoisomers thereof, wherein
• R1 is hydrogen, nitro, cyano, azido, polyhaloC1-6alkyl, and polyhaloC1-6alkoxy;
• R2 is C3-7cycloalkyl optionally substituted with C1-6alkyl;
• C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or Het;
• C2-6alkenyl optionally substituted with C3-7cycloalkyl, aryl or Het;
• aryl;
• Het;
• or —NR4aR4b, wherein R4a and R4b are, each independently, C1-6alkyl, or R4a and R4b together with the nitrogen to which they are attached form a 5- or 6-membered saturated heterocyclic ring;
• R3 is hydrogen, C1-6alkylcarbonyl, C1-6alkyl optionally substituted with aryl, C1-6alkoxy -C1-6alkyl, or C3-7cycloalkyl, C1-6alkyl optionally substituted with Het;
• R4 is hydrogen, hydroxy, halo, nitro, cyano, carboxyl, C1-6alkyl, C1-6alkoxy, C1-6alkoxy -C1-6alkyl or C3-7cycloalkyl, C1-6alkylcarbonyl, amino, mono- or diC1-6alkylamino, azido, mercapto, polyhaloC1-6alkyl, and polyhaloC1-6alkoxy, C1-6alkyl optionally substituted with aryl or Het;
• C3-7cycloalkyl optionally substituted with C1-6alkyl;
• C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or Het;
• C2-6alkenyl optionally substituted with C3-7cycloalkyl, aryl or Het;
• aryl;
• Het;
• or —NR4aR4b,wherein R4a and R4b are, each independently, C1-6alkyl, or R4a and R4b together with the nitrogen to which they are attached form a 5- or 6-membered saturated heterocyclic ring;
• n is one, two, three, four or five;
• p is one, two, three, four or five, independently of n;
• each aryl as a group or part of a group is phenyl or naphthalenyl, each optionally substituted with one, two or three substituents selected from halo, hydroxy, nitro, cyano, carboxyl, C1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, C1-6alkylcarbonyl, amino, mono- or diC1-6alkylamino, azido, mercapto, polyhaloC1-6alkyl, and polyhaloC1-6alkoxy;
• and
• each Het as a group or part of a group is a monocyclic ring with 5 or 6 ring atoms or a bicyclic ring structure comprising a 6 membered ring fused to a 4, 5, or 6 membered ring;
• each of the rings being saturated, partially unsaturated, or completely unsaturated;
• at least one of the rings containing 1 to 4 heteroatoms each independently selected from nitrogen, oxygen and sulphur;
• and any one of the rings being optionally substituted with one, two or three substituents each independently selected from the group consisting of halo, hydroxy, nitro, cyano, carboxyl, C1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, C1-6alkylcarbonyl, amino, mono- or diC1-6alkylamino, azido, mercapto, polyhaloC1-6alkyl, polyhaloC1-6alkoxy, and C3-7cycloalkyl.