Method for treating a homeostasis-related disease or glaucoma by administering a 1,2,3,4-tetrahyroquinoxaline compound

A method for modulating glucocorticoid receptor activity comprising administering a pharmacologically effective amount of a compound or a pharmaceutically acceptable salt thereof to a patient, said compound having the following formula

• (1):
• wherein
• R1 represents a lower alkyl group, a lower cycloalkyl group, an aryl group, a heterocyclic group or an aralkyl group;
• in the case where R1 is a lower alkyl group, the lower alkyl group is unsubstituted or substituted with one or a plurality of groups selected from the group consisting of a halogen atom, a heterocyclic group, a carboxy group, a lower alkoxycarbonyl group, a lower alkylamino group, a lower alkylamino group substituted with a lower alkylamino group and a lower alkylamino group substituted with an aryl group;
• in the case where R1 is an aryl group, a heterocyclic group or an aralkyl group, the aryl group, the heterocyclic group or the aralkyl group is unsubstituted or substituted with one or a plurality of groups selected from the group consisting of a halogen atom, a lower alkyl group, a hydroxyl group and a lower alkoxy group;
• R2 represents a hydrogen atom or a lower alkyl group;
• R3 represents a hydrogen atom or a lower alkyl group;
• R4 and R5 are the same or different and represent a hydrogen atom or a lower alkyl group;
• R6 represents a hydrogen atom or a lower alkyl group;
• R7 represents a lower cycloalkyl group, an aryl group or a heterocyclic group;
• in the case where R7 is an aryl group or a heterocyclic group, the aryl group or the heterocyclic group is unsubstituted or substituted with one or a plurality of groups selected from the group consisting of a halogen atom, a lower alkyl group, a hydroxyl group, a lower alkoxy group and a nitro group;
• W represents an oxygen atom or NR8;
• R8 represents a hydrogen atom or a lower alkyl group;
• X represents an oxygen atom or a sulfur atom;
• Y represents a lower alkylene group;
• Z represents an oxygen atom, a sulfur atom, NR9 or OCO;
• and
• R9 represents a hydrogen atom or a lower alkyl group.