# US 8,569,487 B2 · Pyridazine compound and use thereof

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- Number: US 8,569,487 B2
- Document ID: US8569487B2
- Status: Granted
- Kind: B2
- Application number: 12/303,207
- Filed: 2007-07-06
- Published: 2010-03-11
- Granted: 2013-10-29
- Earliest claimed: 2006-07-07
- Assignees: Gilead Sciences, Inc.; K.U. Leuven Research & Development; Gerhard Puerstinger
- Applicants: Steven S. Bondy; Terrence C. Dahl; David A. Oare; Reza Oliyai; Winston C. Tse; Vahid Zia
- Inventors: Steven S. Bondy; Terrence C. Dahl; David A. Oare; Reza Oliyai; Winston C. Tse; Vahid Zia
- Web page: https://patentgrep.com/patent/US8569487B2

## CPC

- C07D 403/14: containing three or more hetero rings
- A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 31/12: Antivirals
- A61P 31/14: for RNA viruses
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections. Methods of making and formulating compound (1) are provided.

## Claims

### Claim 1

A compound of formula (3)
and its analogues substituted with methyl rather than chloromethyl; and bromo, fluoro or iodo in place of chloro.